Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia

By S. Ripke, C. O’Dushlaine, K. Chambert, J. Moran, A. Kähler, S. Akterin, Sarah E. Bergen, Ann L. Collins, J. Crowley, Menachem Fromer and 158 more. Nature Genetics, 2013

740 citations recorded by the source corpus.

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300–10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

Subfields: Genetics, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/159b8bca0b80b646c4b393861c1d1f5afbbde319

Citations in the corpus