Faculty Opinions recommendation of NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

By P. Anand. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019

745 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/15800963f3749127851a5d272bc16cdada2526c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. H. D. Alexander
2. I.Maeve Rea
3. Owen A. Ross
4. David S. Gibson
5. Victoria McGilligan
6. S. Mcnerlan

Citations in the corpus

• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, positive): “By self-limiting the host response, the NF-κB-p62 mitophagy pathway maintains homeostasis which under normal conditions leads to tissue repair (75).”
• The mitophagy pathway and its implications in human diseases (2023, neutral): “NLRP3 inflammasome activation causes nuclear factor kappa B subunit (NFKB/NF-κB) to selectively induce SQSTM1 accumulation on mitochondria, thereby initiating mitophagy to exert its anti-inflammatory effect.(311) Studies have also found that levels of the stress inducible protein senstrin 2 (Sesn2) ”