Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy
By Michael Keidar, R. Walk, A. Shashurin, Priya Srinivasan, A. Sandler, S. Dasgupta, R. Ravi, Rafael Guerrero-Preston, B. Trink. British Journal of Cancer, 2011
712 citations recorded by the source corpus.
Background:Plasma is an ionised gas that is typically generated in high-temperature laboratory conditions. However, recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature.Methods:Both in-vitro and in-vivo studies revealed that cold plasmas selectively kill cancer cells.Results:We show that: (a) cold plasma application selectively eradicates cancer cells in vitro without damaging normal cells; and (b) significantly reduces tumour size in vivo. It is shown that reactive oxygen species metabolism and oxidative stress responsive genes are deregulated.Conclusion:The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation of cancer treatment technologies by utilisation of another state of matter.
Subfields: Aerospace Engineering, Electrical and Electronic Engineering, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/156ff8d4d90b1a3bc0028c5b7f427606703cc56e
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Citations in the corpus
- Physicochemical properties of bactericidal plasma-treated water (2016, background): “Many studies have investigated the potential applications of LTAPP; in particular, the field of plasma medicine has attracted intense interest [3–5] with regards to enhanced wound healing [3, 4, 6], cancer therapy [7, 8], inactivation of pathogenic amyloids [9, 10], disinfection of the human body or”
- A review of recent applications of atmospheric pressure plasma jets for materials processing (2015, background): “Keidar et al.80,83 discussed the great potential of cold plasma in tumor ablation and eradicating cancer cells in vitro without damaging normal cells and in reducing tumor size in vivo.”