Protein-Protein Interactions

2012

351 citations recorded by the source corpus.

Synopsis Virtually all vital cellular processes are controlled by protein-protein interactions (PPIs), including gene expression, proliferation, intracellular communication and apoptosis. The understanding and manipulation of PPIs therefore plays an important role in fathoming the biology of healthy and diseased states. Achieving this goal will lead to new probes of cell signalling pathways or systems biology, and molecular therapeutics for addressing unmet medical needs. To date, only a few PPIs have been the subject of drug discovery initiatives by the pharmaceuticals industry. Given the potential opportunities around modulating more of the estimated >650,000 PPIs, this field continues to generate considerable scientific interest, which has stimulated significant academic and industrial innovation. This meeting will address recent advances in the area. Topics will include: inducing protein degradation using small molecules, protein engineering and synthetic biology, integration of computational and experimental methods to study PPIs, characterisation and identification of new PPI inhibitors and lead optimization challenges for molecules targeting PPIs from case studies in drug discovery. Speakers from both industry and academia will describe strategies for addressing these challenges whilst showcasing the opportunity for creativity and innovation. The event is aimed at all scientists (including PhD students and those in early career), from industry and academia, with an interest in the understanding or manipulation of protein-protein interactions. This encompasses medicinal and computational chemists, structural biologists, biochemists, chemical biologists, and molecular and cell biologists.

Subfields: Infectious Diseases, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/156272369882f630bbcf710670950de78d595ef3