The Dorsoventral Regulatory Gene Cassette spätzle / Toll / cactus Controls the Potent Antifungal Response in Drosophila Adults

By Jonathan C. Kagan. 2015

1,017 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/14fb6b2fdb53cfe05ba61c8b64b789ab9bf8f9d0

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1. Philipp Engel
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4. Kui Li
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6. Danyang Li
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8. Minghua Wu

Citations in the corpus

• Immune sensing of DNA (2013, unknown): “The first identified—and best characterized—class of PRRs is the Toll-like receptors (TLRs) (Lemaitre et al., 1996; Medzhitov et al., 1997), which are expressed on the cell surface and in endosomal compartments, in order to respond to extracellular and endosomal PAMPs and DAMPs.”
• The gut microbiota of insects - diversity in structure and function. (2013, background): “In the systemic immune response of D. melanogaster, Toll and IMD are the two major signaling pathways inducing AMP production (Lemaitre et al., 1995, 1996; De Gregorio et al., 2002).”
• The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “The discovery of the TLR family in the Drosophila fruit fly opened a path towards the elucidation of recognition mechanisms against microbial components by innate immunity cell [3].”
• Encapsulation and nodulation in insects (2016, background): “These genes encode peptides and proteins, which can both target the invader for degradation or act as signaling molecules to induce and enhance the innate immune response such as encapsulation and nodulation (Lemaitre et al., 1996; Marmaras and Lampropoulou, 2009; Myllymaki and Ramet, 2014).”
• Pattern recognition receptors in health and diseases (2021, background): “It has been found that Toll can recognize spatzle (an important protein in the development of the dorsal and abdomen of Drosophila) and initiate a series of signal transduction to activate the expression of antifungal peptide.(19) In 1997, Janeway et al.”
• Toll-like receptors in antiviral innate immunity (2013, background): “First acknowledged in Drosophila, the Toll receptor was shown to be important for host defense against fungal infection [6].”