Interventions to improve the appropriate use of polypharmacy for older people.

By S. Patterson, C. Hughes, N. Kerse, C. Cardwell, M. Bradley. Cochrane Database of Systematic Reviews, 2012

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Clinical consequences of polypharmacy in elderly (2014, background): “Recently two comprehensive reviews have been published about various interventions to improve polypharmacy or unnecessary drug use in older adults (Table 2) [2,46].”
The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010 (2015, background): “Further research is needed to improve our understanding of the risks and benefits of the complex combinations of potentially interacting drugs that happen in the real world, and for trials of interventions to optimise treatment of people with polypharmacy, which evaluate the impact on mortality and ”