Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
By M. Mirjalili, E. Moyano, M. Bonfill, R. Cusido, J. Palazón. Molecules, 2009
617 citations recorded by the source corpus.
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The major chemical constituents of the Withania genus, the withanolides, are a group of naturally occurring C28-steroidal lactone triterpenoids built on an intact or rearranged ergostane framework, in which C-22 and C-26 are appropriately oxidized to form a six-membered lactone ring. In recent years, numerous pharmacological investigations have been carried out into the components of W. somnifera extracts. We present here an overview of the chemical structures of triterpenoid components and their biological activity, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease. The most recent attempts in biotechnological production of withanolides are also discussed.
Subfields: Complementary and alternative medicine
View Paper: https://www.semanticscholar.org/paper/14ccf3490f1071cbb75a0bbd87e70d0bc97e56e7
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Citations in the corpus
- A review on trends in production of secondary metabolites from higher plants by in vitro tissue, organ and cell cultures. (2009, background): “D + BA Callus Mirjalili et al., 2009 Zataria multiflora Rosmarininc acid MS + IAA + Kin Callus Francoise et al., 2007 2-fold increase in the accumulation of adhyperforin (Karppinen et al., 2007).”