Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

By Tor D. Wager, James K. Rilling, Edward E. Smith, A. Sokolik, K. Casey, Richard J. Davidson, Stephen M. Kosslyn, Robert M. Rose, J. Cohen. Science, 2004

1,974 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/14a5e312b5e683bcb84ceb80366d2009617afb89

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Citations in the corpus

The cognitive control of emotion. (2005, background): “Although the precise nature of the cognitive processes mediating placebo effects is not yet clear, placebo-related interactions between prefrontal and appraisal systems are strikingly similar to those supporting reappraisal, suggesting that placebo effects are mediated by the active maintenance of b”
From affect to control: Functional specialization of the insula in motivation and regulation (2017, methodology): “More methodological detail can be found in our other papers (Phan et al., 2002; Wager, Reading et al., 2004; Wager & Smith, 2003).”
The neural architecture of emotion regulation (2007, background): “This suggests that like reappraisal, placebo effects involve the active maintenance of beliefs about placebo compounds that in turn change the way in which stimuli are appraised top-down (Wager et al., 2004).”
Functional neuroanatomy of aversion and its anticipation (2006, background): “The co-activation of the insula and ACC found in the present study has been reported frequently in research on different forms of aversion (Chua et al., 1999; Ploghaus et al., 1999; Price, 2000; Phelps et al., 2001; Craig, 2002, 2003; Murphy et al., 2003; Wicker et al., 2003; Singer et al., 2004; Wa”
Emotion and the Prefrontal Cortex: An Integrative Review (2017, background): “…et al., 1999; Lieberman & Eisenberger, 2015; Livneh & Paz, 2012; Milad et al., 2007; Mobbs et al., 2009; Mobbs et al., 2010; Phelps, Delgado, Nearing, & LeDoux, 2004; Rainville et al., 1997; Rushworth et al., 2007; Shackman et al., 2011; Vogt, 2005; Wager et al., 2013; Wager et al., 2004).”
The Mechanisms of Manual Therapy in the Treatment of Musculoskeletal Pain: A Comprehensive Model (2008, background): “…descending inhibition due to associated changes in the opioid system (Sauro and Greenberg, 2005), dopamine production (Fuente-Fernandez et al., 2006), and central nervous system (Petrovic et al., 2002; Wager et al., 2004; Matre et al., 2006) which have been observed in studies unrelated to MT.”
Challenging the assumptions for thermal sensation scales (2017, background): “In pain, for example, expectations modulate the perceived pain intensity as demonstrated by placebo analgesia (Wager et al., 2004).”
A taxonomy of external and internal attention. (2011, positive): “…important question is whether there is a core, central mechanism that governs all executive functions or whether there are specific mechanisms for different domains of internal attention (Badre & Wagner 2004, Duncan & Owen 2000, Rushworth et al. 2001, Wager et al. 2004, Wojciulik & Kanwisher 1999).”
Decoding the role of the insula in human cognition: functional parcellation and large-scale reverse inference. (2013, background): “…and socio-emotional processing (Sanfey et al. 2003; Chang et al. 2011), a dorsoanterior region associated with higher cognitive processing (Dosenbach et al. 2006; Eckert et al. 2009), and a posterior insula region associated with pain and sensorimotor processing (Craig 2002; Wager et al. 2004).”
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. (2008, methodology): “In the latter report, these changes were correlated with subjective analgesic effects.(11) Significant covariation of synaptic activity in the PAG and in the rostral anterior cingulate was also observed and interpreted as reflecting an interaction between pain modulatory (eg, PAG) and cognitiveinteg”
The role of lateral orbitofrontal cortex in the inhibitory control of emotion (2006, background): “…suppression or 'gating' of sensory information regulates the amount of information that the organism receives at one time, thereby facilitating the ability to process and organize that information efficiently (Adler et al 1982; Waldo and Freedman 1986; Knight et al. 1989; Freedman et al. 1996).”
A comprehensive review of the placebo effect: recent advances and current thought. (2008, background): “In two functional magnetic resonance imaging (fMRI) experiments published in a single study, Wager et al. (2004) found that placebo analgesia was related to decreased neural activity in pain processing areas of the brain.”
Functional grouping and cortical-subcortical interactions in emotion: A meta-analysis of neuroimaging studies (2008, positive): “Further, pgACC shows increases in activity and opioid release with placebo treatment in pain (Petrovic et al., 2002; Wager et al., 2004a,b; Zubieta et al., 2005).”