Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
By Kevin K. Park, Kai-Fenp Liu, Yang Hu, Patrice D. Smith, Chen Wang, B. Cai, Bengang Xu, Lauren Connolly, I. Kramvis, Mustafa Sahin and 1 more. Science, 2008
1,633 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/141ebd4f4b91dfda4cf075d92c3152ad1d198ade
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In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons (2010, background): “We recently discovered that age- and injury-dependent downregulation of neuronal mTOR activity is a major cause of the lack of regeneration of optic nerve axons after injury and that genetic activation of mTOR promotes successful optic axon regeneratio”
- Rho signaling and axon regeneration. (2012, background): “Similarly, genetic manipulation of PTEN,which acts in the Rho pathway (Park et al., 2008), appears to be more powerful than inhibiting ROCK.”
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 (2011, background): “Although deletion of either phosphatase and tensin homologue (PTEN), a negative regulator of mammalian target of rapamycin (mTOR), or suppressor of cytokine signalling 3 (SOCS3), a negative regulator of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, in adult reti”
- Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury (2012, neutral): “PTEN inhibits the activity of ‘‘mammalian target of rapamycin’’ (mTOR), and neuronal knockout of PTEN has been reported to enhance central axonal regeneration (Park et al., 2008; Liu et al., 2010; Sun et al., 2011).”