The Evidence Ontology: Supporting Conclusions & Assertions with Evidence
By Marcus C. Chibucos, Deborah A. Siegele, James C. Hu, Michelle G. Giglio. 2017
46 citations recorded by the source corpus.
The Evidence Ontology (ECO) is a community resource for describing the various types of evidence that are generated during the course of a scientific study, and which are typically used to support assertions made by researchers. ECO describes multiple evidence types, including evidence resulting from experimental (i.e. wet lab) techniques, evidence arising from computational methods, statements made by authors (whether or not supported by evidence), and inferences drawn by researchers curating the literature. In addition to summarizing the evidence that supports a particular assertion, ECO also offers a means to document whether a computer or human performed the process of making the annotation. Incorporating ECO into an annotation system makes it possible to leverage the structure of the ontology such that associated data can be grouped hierarchically, users can select data associated with particular evidence types, and quality control pipelines can be optimized. Today, over 30 resources, including the Gene Ontology, use the Evidence Ontology to represent both evidence and how annotations are made.
Subfields: Molecular Biology
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Citations in the corpus
- The Gene Ontology Resource: 20 years and still GOing strong (2018, background): “To make this possible, starting in 2018, in collaboration with the Evidence and Conclusions Ontology (29) (2), the GO has added several new evidence codes to describe high-throughput experiments: ‘ECO:0006056 high throughput evidence used in manual assertion’ (HTP), and the subclasses: ‘ECO:0007005 ”
- Human Disease Ontology 2018 update: classification, content and workflow expansion (2018, methodology): “com/ ontodev/robot), has also been implemented in other OBO Foundry ontologies such as the Ontology for Biomedical Investigations (24), the Gene Ontology (25), the Evidence and Conclusion (ECO) ontology (26) and the Immune Epitope Database’s (IEDB) (27) MHC Restriction Ontology (28, http://ceur-ws.”
- Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes (2018, background): “All entries are annotated with Evidence and Conclusion Ontology (ECO) codes (12) that identify the level of experimental evidence that exists for any given complex.”