Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

By Eric Schnell, M. Sizemore, Siavash Karimzadegan, Lu Chen, D. Bredt, R. Nicoll. Proceedings of the National Academy of Sciences of the United States of America, 2002

757 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/13e4b864f8c9c637a28cbbea593689acff5a5c4a

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Citations in the corpus

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo (2006, background): “]. PSD-95 is thought to provide “slots” for AMPA-Rs, and PSD-95 levels at individual synapses could thus determine synaptic strength [”
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach (2009, positive): “We have previously found that stargazin-like TARPs bind to all AMPAR subunits and, via their binding to PSD-95 and related MAGUKs, target receptors to synapses (Chen et al., 2000; Nicoll et al., 2006; Osten and Stern-Bach, 2006; Schnell et al., 2002; Ziff, 2007).”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Another major surprise was that AMPARs do not directly bind to MAGUKs but rather do so via a family of AMPAR auxiliary subunits termed transmembrane AMPAR regulatory proteins (TARPs).”
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, positive): “The prime binding protein for the MAGUK family is the NMDAR subunit NR2,155 but it also binds to the transmembrane AMPAR regulatory proteins (TARPs),43 nonreceptor tyrosine kinases,329 nNOS,30,31 GKAP,217 and AKAP79/150.53 MAGUKs can be seen as the functional scaffold of the PSD and are essential fo”
Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity (2008, methodology): “Hippocampal slice cultures were prepared from 7- to 8-day-old rat pups (Schnell et al., 2002) and maintained in Neurobasal-A medium supplemented with horse serum (Hyclone, Logan, UT), insulin (Sigma), and Glutamax.”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “produced an increase of extrasynaptic AMPARwithout any detectable effect on AMPAR-mediated synaptic transmission (Rouach et al., 2005; Schnell et al., 2002).”
Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “…2009) that selectively interact with AMPA receptors early in synthesis and trafficking and direct proper expression and localization of the receptor at the cell surface (Hashimoto et al., 1999; Chen et al., 2000; Schnell et al., 2002; Tomita et al., 2004, 2005a; Vandenberghe et al., 2005).”
Mechanisms of CaMKII action in long-term potentiation (2012, background): “Rather, the synaptic localization of AMPARs depends on the binding of stargazin to PSD95 (Ref”
Neuroligins determine synapse maturation and function. (2006, background): “PSD-95 also binds to stargazin, which in turn interacts with AMPA receptors (Fukata et al., 2005; Schnell et al., 2002).”
Abundant distribution of TARP γ‐8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites (2006, background): “…receptor expression by TARPs, in which interaction with the cytoplasmic tail of TARPs increases surface AMPA receptors, and the binding of TARPs with PSD-95 targets them to synapses (Chen et al., 2000; El-Husseini et al., 2000; Chetkovich et al., 2002; Schnell et al., 2002; Bredt & Nicoll, 2003).”
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling (2010, background): “…β2AR % GluR1/syn puncta pos. for β2AR % β2AR/syn puncta pos. for GluR1 β 2 AR GluR1 Ig G Ly sa te NR2B β2AR β 2 AR Ig G Ly sa te NR 1 β2AR Ig G PSD95 &2010 European Molecular Biology Organization The EMBO Journal VOL 29 | NO 2 | 2010 483 targeting of AMPARs (Chen et al, 2000; Schnell et al, 2002).”
Regulation of AMPA Receptor Trafficking and Synaptic Plasticity (2012, result): “While some studies have shown that overexpression of SAP97 increases AMPAR function at synapses [25,26], some have suggested otherwise [27,28].”
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. (2003, methodology): “Oregon Health and Science University One synaptic protein with the properties expected ofPortland, Oregon 97239 a slot protein is PSD-95 (Schnell et al., 2002).”