Ferroptosis: past, present and future

By Jie Li, F. Cao, He-liang Yin, Zi-jian Huang, Zhitao Lin, Ning Mao, Bei Sun, Gang Wang. Cell Death and Disease, 2020

3,597 citations recorded by the source corpus.

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases.

Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/13cbbd606656eb3c28a13ee8604eb7471ad17e8f

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In Cancer Research

1. P. Lei
2. Shu-ting Zhang
3. M. Valko
4. Qing-zhang Tuo

In Molecular Biology

1. K. Jomová
2. P. Lei
3. Shu-ting Zhang
4. M. Valko
5. Eugenie Nepovimova
6. Qing-zhang Tuo

In Pulmonary and Respiratory Medicine

1. P. Lei
2. Shu-ting Zhang
3. Qing-zhang Tuo

Citations in the corpus

• Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “Overex-pressed SOD1 has been detected in non-small cell lung cancer (NSCLC), breast cancer, and nasopharyngeal carcinoma (NPC) (Li et al. 2020a, b).”
• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “verts the reduced form of GSH to its oxidized form while reducing lipid hydroperoxides to their corresponding alcohols.(225) The same reaction can also reduce free hydrogen peroxide to water.”