The Polycomb group protein EZH2 directly controls DNA methylation

By Emmanuelle Viré, C. Brenner, Rachel Deplus, L. Blanchon, M. Fraga, C. Didelot, L. Morey, A. Eynde, David Bernard, J. Vanderwinden and 5 more. Nature, 2006

1,149 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1386a6f85e872f6bb69f260c7a12e738bda2f9e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hsueh‐Fen Juan
2. Hsuan-Cheng Huang
3. Arul M. Chinnaiyan
4. Peter A. Jones
5. Yu-Ching Fang
6. T. Miranda
7. G. Almouzni

In Molecular Biology

1. T. Miranda
2. Xiaojing Yang
3. Anja Groth
4. Hsueh‐Fen Juan
5. Hsuan-Cheng Huang
6. Arul M. Chinnaiyan
7. Peter A. Jones
8. Yu-Ching Fang

Citations in the corpus

• Repression of E-cadherin by the polycomb group protein EZH2 in cancer (2008, background): “Oncogene Recently, it has been shown that DNA methyltransferases and EZH2 cooperate in silencing genes such as MYT1,WNT1, KCNA1 and CNR1 (Vire et al., 2006).”
• MeInfoText: associated gene methylation and cancer information from text mining (2008, background): “In addition, the initiation of the process of abnormal promoter methylation may associate with chro-matin-remodelling complexes [5,9].”
• Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. (2007, background): “To gain further mechanistic insight, we also analyzed the promoter occupancy for RNA Pol II, as RNA Pol II and PRC2 are known to occupy gene promoters in a mutually exclusive manner (Lee et al. 2006; Vire et al. 2006).”
• Chromatin challenges during DNA replication and repair. (2007, positive): “DNMT1 interacts with HDACs (Fuks et al., 2000; Rountree et al., 2000), the ATP-dependent chromatin-remodeling enzyme SNF2h (Rob-ertson et al., 2004), the polycomb protein EZH2 that directs H3K27me (Vire et al., 2006), and the H3K9 methyl-transferase G9a (Esteve et al., 2006).”
• DNA methylation: The nuts and bolts of repression (2007, background): “DNAmethyltransferases have been shown to interactwith the histone methyltransferases SUV39, which is responsible for methylation of H3K9, and EZH2, which catalyzes H3K27 methylation (Fuks et al., 2003; Vire et al., 2006).”