Population and evolutionary dynamics of phage therapy

By B. Levin, J. Bull. Nature Reviews Microbiology, 2004

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Efficiency of phage cocktails in the inactivation of Vibrio in aquaculture (2014, background): “Although the development of phage-resistance, when only one phage is used, has already been reported (Levin and Bull, 2004; Merril et al., 2006; Nakai et al., 2010; Sandeep, 2006; Scott et al., 2007; Silva et al., 2013; Skurnik and Strauch, 2006; Tanji et al., 2005; Vieira et al., 2012), this limita”
Phage Therapy in the Postantibiotic Era (2019, background): “Nevertheless, the usefulness of monophage therapy in clinical practice may be hampered by the emergence of bacterial phage resistance, as it can appear relatively quickly, even in small bacterial populations (85, 86).”
Phage cocktails and the future of phage therapy. (2013, background): “Monophage therapy involves the application of only a single phage type, whereas polyphage therapy [28] is the application of a phage cocktail, that is, therapy involving the simultaneous use of more than one phage type (also see ‘multiphage’ [31,32]).”