The economies of synthesis

By Timothy R. Newhouse, P. Baran, R. W. Hoffmann. Chemical Society Reviews, 2009

629 citations recorded by the source corpus.

In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.

Subfields: Catalysis, Environmental Chemistry, Physical and Theoretical Chemistry

View Paper: https://www.semanticscholar.org/paper/12f969ec496ed984a3f069acd68b18544393ecf7

Citations in the corpus

• Organocatalytic cascade reactions as a new tool in total synthesis. (2010, neutral): “as strategic key elements for their synthetic approache”