Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
By M. Ferreira, M. O’Donovan, Y. Meng, I. Jones, D. Ruderfer, Lisa Jones, Jinbo B Fan, G. Kirov, Roy H. Perlis, E. Green and 52 more. Nature Genetics, 2008
1,273 citations recorded by the source corpus.
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10−9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10−8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Subfields: Genetics, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/12e531fa2625f7459fe2175b0d8e90725eaa6282
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In Psychiatry and Mental health
Citations in the corpus
- ScholarWorks @ UTRGV ScholarWorks @ UTRGV (background): “The result of SGRN inference is displayed in Figure 3 where two yellow colored genes, EGFR and CACNA1C, are selected from [23, 24] and the rest of two pairs are from [22].”
- Genetics of bipolar disorder. (2011, background): “As of early 2010, no single BPD sample has yielded a p value below this threshold in a GWAS (Wellcome Trust Case Control Consortium 2007; Baum et al. 2008; Ferreira et al. 2008; Hattori et al. 2009; Scott et al. 2009; Sklar et al. 2008; Smith et al. 2009).”
- The diagnosis of mental disorders: the problem of reification. (2010, background): “There is less information to date about other mental disorders, but progress is being made, most notably in bipolar disorder (Ferreira et al. 2008, Int.”