The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex
By Michael Koenigs, Jordan Henry Grafman. Behavioural Brain Research, 2009
930 citations recorded by the source corpus.
A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.
Subfields: Cognitive Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/12e2334a60c3b907760e04a833da5d3edc03a8e7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- Michael A. Nitsche
- Walter Paulus
- C. J. Stagg
- Felipe Fregni
- David Liebetanz
- Leonardo G. Cohen
- Andrea Antal
- Ulf Ziemann
In Neurology
- Michael A. Nitsche
- Walter Paulus
- Felipe Fregni
- Leonardo G. Cohen
- C. J. Stagg
- Ulf Ziemann
- David Liebetanz
- Andrea Antal
Citations in the corpus
- Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). (2017, background): “The rationale for the use of tDCS in the treatment of depressive disorders is based on the knowledge of functional and structural abnormalities in the left and right dorsolateral and ventromedial prefrontal cortex, amygdala and hippocampus in depressed patients (Campbell et al., 2004; Hamilton et al”
- A technical guide to tDCS, and related non-invasive brain stimulation tools (2015, background): “Thus, in most cases, electrodes are positioned over the area associated with the pathology under study – for instance, in depression electrodes are placed over the dorsolateral prefrontal cortex, an area in which activity is pathologically altered (Koenigs and Grafman, 2009).”
- Cognitive Network Neuroscience (2015, background): “The dorsolateral pFCs (Koenigs & Grafman, 2009) and inferior frontal gyrus (Shamay-Tsoory, Aharon-Peretz, & Perry 2008) have been implicated as nodes in a distributed emotion processing system with differentiable functional roles.”