Hematopoietic stem cell niche maintenance during homeostasis and regeneration

By Avital Mendelson, P. Frenette. Nature Medicine, 2014

714 citations recorded by the source corpus.

The bone marrow niche has mystified scientists for many years, leading to widespread investigation to shed light into its molecular and cellular composition. Considerable efforts have been devoted toward uncovering the regulatory mechanisms of hematopoietic stem cell (HSC) niche maintenance. Recent advances in imaging and genetic manipulation of mouse models have allowed the identification of distinct vascular niches that have been shown to orchestrate the balance between quiescence, proliferation and regeneration of the bone marrow after injury. Here we highlight the recently discovered intrinsic mechanisms, microenvironmental interactions and communication with surrounding cells involved in HSC regulation, during homeostasis and in regeneration after injury and discuss their implications for regenerative therapy.

Subfields: Genetics, Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/12d46d2efb1188dabde15d9248e5f329b8096910

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Citations in the corpus

• Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration (2017, background): “Subsets of bone marrow MSCs, such as C-X-C motif chemokine (CXCL)12-abundant reticular (CAR) cells, provide essential maintenance signals for the hematopoietic stem cell niche (Mendelson and Frenette, 2014; Morrison and Scadden, 2014).”