Lung cancer in never smokers — a different disease

By Sophie Sun, J. Schiller, Adi F. Gazdar. Nature Reviews. Cancer, 2007

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Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2017, neutral): “Global statistics estimate that 15% of lung cancers in men and 53% in women are not attributable to smoking, overall accounting for 25% [2].”
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase (2009, background): “95" language="eng" publish="issue" relation="no"> Introduction Lung cancer is the leading cause of cancer deaths worldwide with non-small cell lung cancer (NSCLC) being the most prevalent form of lung cance”
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma (2020, background): “Adenocarcinoma (LUAD), the most common lung malignancy, is strongly related to tobacco smoking but also the subtype most frequently found in individuals who have reported no history of smoking (‘‘never-smokers’’) (Subramanian and Govindan, 2007; Sun et al., 2007).”
Lung adenocarcinoma promotion by air pollutants (2023, methodology): “(3) Fold changes from the human data were obtained by pairwise comparisons from each individual.”
Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality (2020, background): “Public Health 2020, 17, 2927 12 of 27 east and south Asia are not related to smoking, whereas it is only 15% in the USA [155].”