Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

By D. Wicher, Ronny Schäfer, René Bauernfeind, M. Stensmyr, R. Heller, S. Heinemann, Bill S. Hansson. Nature, 2008

901 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Insect Science, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/12745010f836f35cd72bfe451d222bbd9c6b1b1c

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In Cellular and Molecular Neuroscience

In Insect Science

In Sensory Systems

Citations in the corpus

The Olfactory System (2014, background): “…and pharmacological studies using heterologous cells demonstrated that the insect ORs indeed formed heteromeric ligand-gated cation channels (Sato et al. 2008; Wicher et al. 2008) and that both subunits contribute to the formation of channel pore structure (Nakagawa et al. 2012).”
Common Sense about Taste: From Mammals to Insects (2009, background): “The closest relatives of the Grs are the insect odorant receptors, which have recently been proposed to function as ion channels (Sato et al., 2008; Wicher et al., 2008).”
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. (2009, positive): “Recent analysis has indicated that insect ORs function as odor-gated ion channels (Sato et al., 2008; Wicher et al., 2008), setting them mechanistically apart from metabotropic vertebrate ORs.”
Evolution of insect olfaction. (2011, positive): “Orco acts as a chaperone (Larsson et al., 2004) and also takes part in signal transduction (Sato et al., 2008; Wicher et al., 2008).”
A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila. (2012, positive): “Ca imaging of CHO cells was performed as described (Wicher et al., 2008).”
Olfactory information processing in Drosophila. (2009, neutral): “Two recent studies [13,14] have proposed that Or83b contributes to an odorantgated cation channel, although they differ as to whether this is directly odorant-gated or relies on an intermediate”
Non-Canonical Odor Coding in the Mosquito (2020, background): “ORs are odorant-gated ion channels (Butterwick et al., 2018; Sato et al., 2008; Wicher et al., 2008) that are formed by a heteromultimeric complex of the conserved co-receptor Orco and a ligand-sensitive OR (Benton et al.”