Beyond the connectome: How neuromodulators shape neural circuits

By Cori Bargmann. 2012

494 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, neutral): “Neuromodulators provide an evolutionarily conserved mechanism to generate behavioral variability (Bargmann, 2012; Marder, 2012).”
OpenWorm: an open-science approach to modeling Caenorhabditis elegans (2014, background): “Neurons communicate with electrical signals, but it is often over-looked that the nervous system itself is awash in a chemical environment that interacts with the electrical signaling processes (Bargmann, 2012; Cohen and Sanders, 2014).”
From the neuron doctrine to neural networks (2015, background): “Moreover, a proper synthesis needs to be carried out, integrating the new anatomical and physiological large-scale datasets (termed ‘struc-tural’ and ‘functional’ connectomics), and evaluating how neuromodulators can alter their function 185,186 .”
Coming to terms with fear (2014, background): ““Global organismic states” in mammals and other vertebrates, like the survival circuits that initiate them, are elaborations of similar states in invertebrates (151, 154, 155).”
Motor primitives in space and time via targeted gain modulation in cortical networks (2018, background): “In line with known physiological effects [6, 8, 26, 28], 135 we have shown that relatively subtle changes in neuronal excitability in cortical circuits can have 136 dramatic effects on ensuing muscular activity, suggesting the possibility that gain modulation is a 137 central part of neuronal motor ”
Questions and controversies in the study of time-varying functional connectivity in resting fMRI (2020, unknown): “Regional and global release of these molecules can lead to drastic changes in the dynamics of neural circuits (Bargmann, 2012; Bargmann & Marder, 2013), and growing evidence suggests that neuro-modulatory systems play a key role in triggering and sculpting the reconﬁguration of functional brain…”
NEUROMODULATION OF NEURONAL CIRCUITS: BACK TO THE FUTURE (2012, background): “But the experience of the small-circuit community (Bargmann, 2012; Brezina, 2010; Getting, 1989; Jang et al., 2012; Marder and Bucher, 2007; Marder and Calabrese, 1996) demonstrates unambiguously that a connectivity diagram is only a necessary beginning, but not in itself, an answer.”
The human connectome: Origins and challenges (2013, background): “The inability of connectome maps to capture modulatory processes has been cited as a major limitation of the structural approach inherent in all of connectomics (Bargmann, 2012; Brezina, 2010; Marder, 2012).”
The theory of constructed emotion: an active inference account of interoception and categorization (2017, unknown): “in chemicals called neurotransmitters, which permit neurons to pass information to one another (Doya, 2008; Bargmann, 2012).”