Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission
By Xintian Xu, Ping Chen, Jingfang Wang, Jiannan Feng, Hui Zhou, Xuan Li, Wu Zhong, Pei Hao. Science China Life Sciences, 2020
2,094 citations recorded by the source corpus.
Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China; National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; The Joint Program in Infection and Immunity: a. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China; b. Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
Subfields: Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/11ffbbd3c696a8760c4198ee96ea83dfb4614800
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Citations in the corpus
- Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence (2020, neutral): “[22] showed 99% similarity between SARS-CoV-2 isolated from”
- C-reactive protein levels in the early stage of COVID-19 (2020, background): “[8] Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al.”
- Return of the Coronavirus: 2019-nCoV (2020, background): “Initial structural modeling suggest that the 2019-nCoV may be able to use human ACE2 as a receptor, although its affinity m be reduced relative to the epidemic SARS-CoV strains [35].”
- SARS-CoV-2 and viral sepsis: observations and hypotheses (2020, background): “The receptor-binding domains of the spike proteins between SARS-CoV-2 and SARS-CoV show a high degree of consistency, 24, 25 and SARS-CoV-2 RNA was also detected in blood samples.”
- Coronavirus disease 2019 (COVID-19): current status and future perspectives (2020, background): “The genome sequencing has demonstrated that this pneumonia named COVID-19 is caused by a novel coronavirus SARS-CoV2, formally known as 2019-nCoV [11-13].”
- SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat (2020, methodology): “The phylogenetic analysis of SARSCoV-2 against a collection of coronavirus sequences from various sources found that SARS-CoV-2 belonged to the Betacoronavirus genera and was closer to SARS-like coronavirus in bat [19].”
- COVID-19 and Multiorgan Response (2020, neutral): “It also shares the same cellular receptor as SARS-CoV which is the angiotensin-converting enzyme 2 (ACE2) receptor.(12) ACE2 receptors are enriched in alveolar epithelial type II cells of lung tissues,(13) as well as extrapulmonary tissues such as the heart, endothelium, kidneys, and intestines,(14,”
- Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study (2020, background): “11 COVID-19 is transmitted through respiratory droplets, physical contact, and aerosols, and there is evidence of human-to-human transmission.”
- COVID-19 with Different Severities: A Multicenter Study of Clinical Features (2020, background): “SARS-CoV-2 has a receptor-binding domain structure similar to that of SARS-CoV, as shown by homology modeling (1).”