Circulating nucleic acids (CNAs) and cancer--a survey.
By M. Fleischhacker, B. Schmidt. Biochimica et Biophysica Acta, 2007
877 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/11d5ec6cdbe53cc124d38bde39b6c164a87f4971
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In Cancer Research
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Citations in the corpus
- Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “It consists of very short (< 200 bp) double-stranded DNA fragments obtained at very low concentrations [193] [194] [195] .”
- Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments (2022, background): “1–10% of the total circulating cell-free DNA (cfDNA), whose normal plasma levels range from 10–100 ng/ml [89].”
- Cell-free nucleic acids as biomarkers in cancer patients (2011, background): “cfNA yields are higher in patients with malignant lesions than in patients without tumours, but increased levels have also been quantified in patients with benign lesions, inflammatory diseases and tissue traum”
- Origins, structures, and functions of circulating DNA in oncology (2016, background): “In addition, extracellular DNA molecules are found and released in cell culture supernatants either from cell lines, primary cells, organoids, or embryo cultures [1].”
- Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA (2015, background): “5 hours in circulation due to rapid hepatic and renal clearance, ctDNA reflects a realtime genomic signature of the tumor versus NGS of archival tissues which may only reflect the cancer’s status at an earlier static time point [20,21].”
- Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin (2016, neutral): “The cfDNA comprises double-stranded DNA fragments that are overwhelmingly short ( 200 base-pairs (bp)) and normally at a low concentration (Fleischhacker and Schmidt, 2007).”