Gene Duplication and Evolution

By Michael Lynch. Science, 2002

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Genome duplication in amphibians and fish: an extended synthesis (2011, background): “…duplication (WGD), and is thought to be fundamental for speciation, diversification of gene functions and shaping genomic architecture across major eukaryotic groups (Lynch, 2002; Ramsey & Schemske, 2002; Blanc, Hokamp & Wolfe, 2003; Leitch et al., 2004; Wessler & Carrington, 2005; Chen, 2007).”
Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes (2004, background): “…was involved in the speciation event that gave rise to these two lineages because duplications followed by deletions and chromosomal rearrangements lead to the reassignment of gene locations, which is a powerful mechanism for creating reproductive isolation between species (Lynch, 2002).”
Teleost fish with specific genome duplication as unique models of vertebrate evolution (2010, background): “This is based on the theoretical prediction that the differential evolution of duplicated genes among populations causes reproductive incompatibility via reduction in fitness of hybrids, resulting in speciation (Ferris et al. 1979; Werthand and Windham 1991; Lynch and Force 2000; Lynch 2002).”