Convergent solutions to binding at a protein-protein interface.
By W. Delano, M. Ultsch, A. D. Vos, J. Wells. Science, 2000
644 citations recorded by the source corpus.
Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/116807a7b76a34d8c87e0653113a084dcb69bd62
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Yana Bromberg
- Maximilian Hecht
- David Baker
- Burkhard Rost
- Ruth Nussinov
- Andrew Leaver-Fay
- Haim J. Wolfson
- David R. Hall
In Radiology, Nuclear Medicine and Imaging
- Bing Xia
- Dima Kozakov
- Sandor Vajda
- Ruth Nussinov
- Haim J. Wolfson
- David R. Hall
- Brian Kuhlman
- Buyong Ma
Citations in the corpus
- Principles of docking: An overview of search algorithms and a guide to scoring functions (2002, background): “64–67 Current data suggest that they preferentially bind at the same binding site.”
- News from the protein mutability landscape. (2013, background): “Indeed, hot spots have been observed to have a high propensity for interaction with multiple partners [54].”
- Design of therapeutic proteins with enhanced stability (2009, background): “(14) showed that the consensus binding region of the antibody (i.”
- Reaching for high-hanging fruit in drug discovery at protein–protein interfaces (2007, background): “Proteins involved in protein–protein interactions can be 'promiscuous', binding to several targets using the same hotspot regio”
- Small-molecule inhibitors of protein–protein interactions: progressing towards the dream (2004, background): “In addition, for many protein–protein interactions, the apparent complementarity between the two surfaces involves a significant degree of protein flexibility and adaptivit”
- The FTMap family of web servers for determining and characterizing ligand binding hot spots of proteins (2015, background): “It has been established that the binding sites of macromolecules include smaller regions called hot spots that are major contributors to binding free energy, and hence they are crucial to binding any ligand at that particular site 1–3 .”
- Computationally Designed Bispecific Antibodies Using Negative State Repertoires (2016, background): “We sought to avoid this averaging by crystallizing the two chains with chain A bound to the Fc-III peptide (DeLano, 2000) at the hinge between CH2 and CH3, but where chain B’s ability to bind Fc-III had been ablated by three mutations: M252E, I253A, & H435A.”