Experimental Physiology - Research Paper Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

By P. Rasmussen, P. Brassard, M. A. Pedersen, L. Leick, E. Hart, Niels H. Secher, B. K. Pedersen, H. Pilegaard. 2014

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Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Studies in humans show that BDNF is released from the brain during a bout of bicycle exercise (95, 96), and aerobic exercise training for 3 months increases the volume of the hippocampus in healthy individuals by 12% and by 16% in patients with schizophrenia (97).”
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate (2016, background): “Brain is a major source of the secretion of BDNF after exercise (Rasmussen et al., 2009).”
Exercise is the real polypill. (2013, background): “Increased BDNF transcripts in exercised rodents’ brains are well documented, providing mechanistic support for a beneficial exercise effect in cognitive function (4, 5, 30, 153, 193, 275, 315, 333, 334, 352, 396, 417, 425, 460, 488, 507), e.”