Pan-cancer multi-omic integration of Trop2 reveals biological determinants and translational implications for ADC therapy

By G. Notini, B. Galbardi, G. Viale, M. M. Naldini, C. Bosi, G. Micheli, L. Licata, M. Mariani, M. Piras, C. Criscitiello and 12 more. 2026

Subfields: Genetics, Molecular Medicine, Oncology

Citations in the corpus

• TROP2 expression in head and neck squamous cell carcinoma: association with the tumor immune microenvironment and clinical outcome (2026, unknown): “…TROP2 expression appears to re fl ect the epithelial lineage, shaping the tumor microenvironment and differentiation state of tumor cells (33), rather than acting solely as a marker of aggressive tumor biology, while reduced expression has been observed in poorly differentiated squamous…”