Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.

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An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. (2010, background): “In the Tucson study, persistent wheezing between ages 3 and 6 years, which is associated with an asthmatic phenotype, was associated with lower FEV1 during early adulthood (age, 16 yr) (107).”
Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (2007, neutral): “Continued followup on lung function measures taken at 11–16 years of age found that, compared to the group of children who experienced no asthma symptoms for the first 6 years of life, the group of children whose asthma symptoms began before 3 years of age experienced significant deficits in lung fu”
Epidemiology of Asthma in Children and Adults (2019, neutral): “The majority of studies have shown that persistent wheeze is related to reduced lung function development throughout adolescence (31, 45, 152, 153), while some suggest the effects of persistent wheeze and relapsed wheeze on lung function are established from mid-childhood, without further decline in”
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report (2007, background): “Persistent asthma begins in the preschool years and alterations in lung structure and function that are present at this time may determine asthma status and lung function throughout childhood and adolescence (11).”