Recent trends in preparation, investigation and application of polysaccharide-based chiral stationary phases for separation of enantiomers in high-performance liquid chromatography

By B. Chankvetadze. Trends in Analytical Chemistry (TrAC), 2020

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Abstract This review article summarizes the recent developments in preparation, investigation and application of polysaccharide-based chiral stationary phases for the separation of enantiomers in high-performance liquid chromatography (HPLC). In the preparation part the major emphases is placed on covalent immobilization of chiral selector (CS) onto the surface of silica, as well as to the application of monolithic and superficially porous silica as carriers for a CS. In the investigation part the emphases is placed on the thermodynamics of the separation process. In the application part the emphases is made on the combination of chemo- and enantioselectivity, on fast separation of enantiomers, obtaining high separation factors and new potential applications related to this. Traditional applications of polysaccharide-based chiral stationary phases, such as to pharmaceutical, bioanalytical, environmental and food analyses are not included due to space limitation of the present review paper.

Subfields: Biomedical Engineering, Spectroscopy

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