Generation of human induced pluripotent stem cells from dermal fibroblasts

By W. Lowry, Laura Richter, Robin Yachechko, A. Pyle, J. Tchieu, Rupa Sridharan, A. Clark, Kathrin Plath. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,062 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/102c1f40234863a517d3afc88895213fde1be8b6

How researchers see this paper

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In Molecular Biology

1. S. Yamanaka
2. K. Hochedlinger
3. M. Stadtfeld
4. R. Jaenisch
5. Kathrin Plath
6. G. Daley
7. A. Soufi
8. K. Zaret

Citations in the corpus

• Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “, different transgenes, vectors and small molecules) as well as different source cells likely result in different paths of reprogramming (Jaenisch and Young, 2008; Lowry et al., 2008), each of which has the potential by genetic and/or epigenetic mechanisms to result in cells that are not fully repro”
• Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. (2011, neutral): “Human induced pluripotent stem cells (HiPSCs) have been generated from human somatic fibroblasts (Lowry et al., 2008; Park et al., 2008; Takaha-shi et al., 2007; Yu et al., 2007) and other human cell types, including CD34 + cells from peripheral blood (Loh et al., 2009), keratinocytes (Aasen et al.,…”
• Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Since then, induced pluripotent stem (iPS) cells have been derived from cells of multiple origin, including human adult fibroblast and keratinocytes (Takahashi et al. 2007; Yu et al. 2007; Lowry et al. 2008; Park et al. 2008).”
• Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA (2010, background): “…no ESC-like colonies had appeared in the retrovirally transduced cultures by this time point, and colonies began to emerge only on the 24th day posttransduction, a time point consistent with previous reports describing iPSC derivation by retroviruses (Lowry et al., 2008; Takahashi et al., 2007).”
• The role of the Hedgehog signaling pathway in cancer: A comprehensive review. (2017, background): “in the maintenance of somatic stem cells and pluripotent cells important for tissue repair [3], such as mammary [4], skin [5], neural [6], erythropoietic [7], and lung stem cells [8], as well as some epithelial cells of internal organs [9].”