Mitochondrial Dysfunction in Atherosclerosis

By N. Madamanchi, M. Runge. Circulation Research, 2007

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How researchers see this paper

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Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases (2011, positive): “This reaction is important in common conditions leading to endothelial and mitochondrial dysfunction, including hypercholesterolemia, hypertension, diabetes, and aging, in which vascular production of O 2 - is increased (83, 146).”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “Mitochondrial-derived oxidative stress has also been implicated in chronic inflammation, cancer progression (206), diabetes mellitus (148, 152, 317–319, 378), and atherosclerosis (21, 258).”
New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis (2018, background): “Elevated mitochondrial ROS is also associated with increased oxidation of LDL, vascular smooth muscle cell apoptosis, and endothelial cell dysfunction, all of which promote atherosclerosis [27].”
Crosstalk between mitochondria and NADPH oxidases (2011, background): “considered initiating events for atherosclerosis [132].”