Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.

By N. Kauff, J. Satagopan, Mark E. Robson, Lauren Scheuer, M. Hensley, C. Hudis, N. Ellis, J. Boyd, P. Borgen, R. Barakat and 4 more. New England Journal of Medicine, 2002

1,200 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Ovarian cancer in the world: epidemiology and risk factors (2019, neutral): “Salpingooophorectomy in BRCA-positive individuals reduces the risk of ovarian cancer by 75%.(112) Since, most epithelial cancers originate from the fallopian tube, salpingectomy decreases the risk of ovarian cancer by 35–50%.”
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. (2006, background): “Clinical options for women at high genetic risk of breast cancer include screening starting at a young age,(19) the use of highly sensitive detection methods,(20) and prophylactic surgeries of the ovaries or breast.(21-27) Because prophylactic surgeries, while highly effective in reducing risk, are ”
Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers with Cancer Risk and Mortality (2010, neutral): “Salpingo-oophorectomy has been demonstrated to decrease the risk of both breast cancer and ovarian cancer in BRCA1/2 mutation carriers.(7-16) However, estimates for risk and mortality reduction for women with and without”
Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. (2004, neutral): “Postmenopausal after oophorectomy 66 (19) 42 (4) 12 (3) 120 (7)”