Preliminary Study on the Isolation of Endophytic Fungus of Catharanthus roseus and Its Fermentation to Produce Products of Therapeutic Value

By Ling Zhang, Guo Bo, Haiyan Li, Zeng Songrong, Shao-feng Hua, Guochen Su, Rongcheng Wei. 2000

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NATURAL PRODUCTS: A CONTINUING SOURCE OF NOVEL DRUG LEADS (2013, background): “Examples are paclitaxel (Taxol®) from Taxomyces [158] and many Pestalotiopsis species [159], as well as camptothecin [160, 161], podophyllotoxin [162, 163], vinblastine [164], and vincristine [165, 166], all produced in relatively small amounts by endophytic fungi isolated from the producing plants.”
Fungal endophytes: unique plant inhabitants with great promises (2011, background): “Vincristine, another anticancer drug originally obtained from Catharanthus roseus (Apocynaceae), was detected in cultures of Fusarium oxysporum endophytic in the same plant (Lingqi et al. 2000).”
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products (2010, background): “Preliminary evidence was reported for the production of vincristine, originally obtained from Catharanthus roseus, by endophytic Fusarium oxysporum isolated from the same plant (Lingqi et al. 2000).”
Bioactivity and genetic diversity of endophytic fungi in Rhododendron tomentosum Harmaja (2011, background): “Vincristine is also produced by endophytic Fusarium oxysporum isolated from this host (Lingqi et al. 2000).”
Endophytic fungi for producing bioactive compounds originally from their host plants (2010, unknown): “roseus that could produce vincristine [66].”