From unwinding to clamping — the DEAD box RNA helicase family

By Patrick Linder, Eckhard Jankowsky. Nature reviews. Molecular cell biology, 2011

1,099 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0fb333c66c93be5f3f082c750e8c8430940e905b

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In Molecular Biology

1. M. Sokabe
2. C. Fraser
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Citations in the corpus

• Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5 (2015, neutral): “In accordance with the canonical functions of the various conserved helicase motifs [59] and the footprint spanning 9–10 bp of dsRNA according to crystal structures [30], the SF2 helicase family conserved motifs primarily involved in RNA binding are motifs Ia [29, 30], Ib and Ic [28, 29], IIa [28–30”
• Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B (2011, background): “A current model suggests that duplex binding by a DEAD-box helicase results in local strand separation.(11,12) A detailed”
• RNA binding activates RIG-I by releasing an autorepressed signaling domain (2019, background): “That said, if RIG-I is capable of displacing proteins from long RNA targets, it is expected to proceed through the winch-like mechanism that is commonly observed for protein displacement by DEAD-box proteins (40), as RIG-I and related ATPases are structurally and phylogenetically related to DEAD-box”
• Toward a Kinetic Understanding of Eukaryotic Translation. (2018, background): “A limited unwinding potential of eIF4F may be caused by the fact that eIF4A, like other DEAD-box helicase proteins, functions as a nonprocessive helicase in the absence of eIF4G (Linder and Jankowsky 2011; García-García et al. 2015).”
• ATP-dependent effector-like functions of RIG-I like receptors (2015, background): “The DExD/Hmotif helicases are nucleic acid-dependent ATP hydrolases and are involved in a broad spectrum of cellular functions, from transcription, splicing, and translation to antiviral immunity (Linder and Jankowsky, 2011).”
• DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense (2020, background): “As a result of their diversity of binding and function, DEAD-box RNA helicases are involved in all aspects of cellular RNA metabolism, including transcription, splicing, microRNA biogenesis, ribosomal RNA processing, RNA export, translation, RNP granule formation, and decay [10].”