Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

By Camille J. Delebecque, A. Lindner, Pamela A. Silver, F. Aldaye. Science, 2011

614 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods (2012, background): “Thus, without further engineering (for example, using scaffolds that physically couple enzymes 76 ), predicted biosynthetic pathways may not yield a product in vivo .”
RNA-based Therapeutics- Current Progress and Future Prospects (2012, background): “Finally, although no clinical applications have yet been demonstrated, RNA aptamers can be engineered to form self-organizing RNA scaffolds (Delebecque et al., 2011), combined with ribozymes to create ‘‘riboswitches’’ (Serganov and Patel, 2007), or conjugated to miRNAs to create ligandresponsive miR”
Genome regulation by long noncoding RNAs (2012, neutral): “complex regulatory scripts out of lncRNAs (107).”
RNA design rules from a massive open laboratory (2014, background): “This Massive Open Laboratory template could be generalized to a broad class of biomolecule design problems, including mechanistic dissection of current design rules (26), modeling of pseudoknots, engineering of RNA switches for cellular control (5, 6), and 3D modeling and design, all assessed by hig”