Biodegradable Gold Nanovesicles with Ultra-Strong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy
By Peng Huang, Jing Lin, Wanwan Li, Pengfei Rong, Zhe Wang, Shouju Wang, Xiaoping Wang, Xiaolian Sun, M. Aronova, G. Niu and 3 more. Angewandte Chemie, 2013
643 citations recorded by the source corpus.
Hierarchical assembling of gold nanoparticles (GNPs) allows one to engineer the localized surface plasmon resonance (LSPR) peaks to the near-infrared (NIR) region for enhanced photothermal Therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) Imaging and PTT. The disulfide bond (S-S) termed PEG-b-PCL block copolymer graft allows dense packing of GNPs during the assembly process and induces ultra-strong plasmonic coupling effect between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η= 37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. These vesicle-architectures assembling of various nanocrystals with tailored optical, magnetic, and electronic properties opens new possibilities for constructing multifunctional biodegradable platforms for biomedical applications, particularly in cancer theranotics.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0f4c0a07f628898925dc33a1608e3dc07457a1ac
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
Citations in the corpus
- Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment (2017, methodology): “An additional technique used for image guidance and assessment of PTT is photoacoustic (PA) imaging (Figure 6(b)).(32,88) In PA imaging, tissue is irradiated with a pulsed laser and light absorption produces a temperature rise in the tissue leading to its subsequent thermo-elastic expansion.”