Unraveling the mysteries of serum albumin—more than just a serum protein

By A. Merlot, D. Kalinowski, D. Richardson. Frontiers in Physiology, 2014

599 citations recorded by the source corpus.

Serum albumin is a multi-functional protein that is able to bind and transport numerous endogenous and exogenous compounds. The development of albumin drug carriers is gaining increasing importance in the targeted delivery of cancer therapy, particularly as a result of the market approval of the paclitaxel-loaded albumin nanoparticle, Abraxane®. Considering this, there is renewed interest in isolating and characterizing albumin-binding proteins or receptors on the plasma membrane that are responsible for albumin uptake. Initially, the cellular uptake and intracellular localization of albumin was unknown due to the large confinement of the protein within the vascular and interstitial compartment of the body. Studies have since assessed the intracellular localization of albumin in order to understand the mechanisms and pathways responsible for its uptake, distribution and catabolism in multiple tissues, and this is reviewed herein.

Subfields: Cell Biology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/0f40b0526b7b40ad728f20237f5532e29c9a552e

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Citations in the corpus

• Albumin-based drug delivery: harnessing nature to cure disease (2016, background): “Investigations of albumin interactions with Gp18 and Gp30 receptors have not been extensively explored, yet it has been shown that modified albumin is degraded faster than native albumin [10, 45] and that chemically modified bovine serum albumin (BSA) shows 1000-fold higher affinity for Gp18 and Gp3”