New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus

By S. de Jong, E. R. Arias, D. Rijkers, C. F. van Nostrum, J. Kettenes-van den Bosch, W. E. Hennink. 2001

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An overview of the recent developments in polylactide (PLA) research. (2010, background): “De Jong et al. (2001) observed PLA depolymerization by a progressive release of dimers in alkaline conditions.”
Bio-Nanocomposites for Food Packaging Applications (2013, background): “The degradation of polyester materials like PLA is eported to occur by uptake of water followed by hydrolysis f ester bond, fragmentation into oligomer, solubilization f oligomer fragments, diffusion of soluble oligomers, and nal mineralization into CO2 and H2O [95].”
Polymer biodegradation: mechanisms and estimation techniques. (2008, background): “De Jong et al. (2001) observed PLA depolymerisation by a progressive release of dimers in alkaline conditions (Fig.”
Hydrolysis and Biodegradation of Poly(lactic acid) (2017, background): “It is often reported that the hydrolysis mechanism at acidic pH proceeds via chain-end scission [59,58].”
Towards Controlled Degradation of Poly(lactic) Acid in Technical Applications (2021, background): “In particular, at neutral or basic pH, the hydrolytic degradation occurs preferentially through backbiting reactions, although a minor contribution of random scission hydrolysis was observed [91].”