Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

By Sheldon Cohen, Denise Janicki-Deverts, William Doyle, Gregory E. Miller, E. Frank, B. Rabin, R. Turner. Proceedings of the National Academy of Sciences of the United States of America, 2012

1,255 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/0ef1ca2137497e4740eba099aafaa105c49987dd

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Citations in the corpus

Minority Stress and Physical Health Among Sexual Minorities (2013, background): “Research in psychoneuroimmunology has consistently linked social stressors to increased inflammation, as indicated by circulating levels of proinflammatory cytokines (e.g., Cohen et al., 2012; Steptoe, Hamer, & Chida, 2007).”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “Consistent with the notion that these effects may also be due in part to altered glucocorticoid dynamics, a different study reported that experiencing even one recent major life event (as rated by the LEDS) predicts greater glucocorticoid resistance (Cohen et al., 2012).”
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, positive): “…been thought to reflect “glucocorticoid resistance,” a particular kind of dysregulation whereby immune cells (e.g., macrophages) become insensitive to the GR-mediated inhibitory effects of cortisol after prolonged overexposure (Kuhlman et al., 2017; Miller et al., 2002, 2011; Cohen et al., 2012).”
The Impact of Racism on Child and Adolescent Health (2019, background): “31 As an example, racial disparities in the infant mortality rate remain, 32 and the complications of low birth weight have been associated with perceived racial discrimination and maternal stress.”
Stress and depression: old questions, new approaches (2015, background): “There is increasing recognition that chronic stress, such as challenging marital, financial and work conditions, is a robust predictor of depression [8], as well as other psychopathologies, maladaptive behaviors, and poorer health outcomes [9,10].”
Stress and Health: A Review of Psychobiological Processes. (2020, result): “Both human and animal studies have provided support for this hypothesis (Miller et al., 2008; Cohen et al., 2012).”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…of glucocorticoid resistance as the result of chronic stress or prolonged exposure to inflammatory cytokines can lead to increase predisposition for the release of IL-1beta and other cytokines (Maes et al., 1993, Pariante et al., 1999, Miller et al., 2002a, Pace et al., 2007, Cohen et al., 2012).”
Psychological restoration in urban gardens related to garden type, biodiversity and garden-related stress (2020, background): “Urban gardens contribute to psychological restoration and stress reduction, which research has shown to be related to further positive health effects (Cohen et al., 2012; Thoits, 2010).”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Thus, the presence of these FKPB5 alleles can result in low levels of circulating cortisol and/or GR resistance in PTSD can lead to a pro-inflammatory state via decreases in antiinflammatory GR signaling (Cohen et al, 2012).”
Advances in Continuous Traumatic Stress Theory: Traumatogenic Dynamics and Consequences of Intergroup Conflict: The Palestinian Adolescents Case (2013, background): “Chronic psychological stress has been associated with the body losing its ability to regulate the inflammatory response which promotes the development and progression of disease (Cohen et al., 2012).”