Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports

By S. Evans, P. Waller, S. Davis. Pharmacoepidemiology and Drug Safety, 2001

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Active computerized pharmacovigilance using natural language processing, statistics, and electronic health records: a feasibility study. (2009, methodology): “10,11 Increasing access to multiple streams of data, such as data in EHRs, pose many new challenges and possibilities for use in the detection of novel adverse signals.”
The reporting odds ratio and its advantages over the proportional reporting ratio (2004, methodology): “Consequently, the proportional reporting ratio (PRR), which resembles a risk ratio or rate ratio in its distribution and interpretation, has been suggested as an effect measure.(1) The PRR is calculated from ‘numerator data’ only.”
Quantitative signal detection using spontaneous ADR reporting (2009, methodology): “A credibility (or conﬁdence) interval (CI) is used in both Bayesian and frequentist methods (PRR or ROR), or a Chi-squared test, 10 can be used to the same effect.”