Helicobacter pylori in health and disease

By T. Cover, Martin J. Blaser. Gastroenterology, 2009

717 citations recorded by the source corpus.

Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H. pylori is usually the numerically dominant gastric microorganism. H. pylori typically does not cause any adverse effects, but is associated with an increased risk of non-cardia gastric adenocarcinoma, gastric lymphoma and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma have been recently reported to occur more frequently in individuals who lack H. pylori, compared with H. pylori-positive persons. In this review, we discuss biologic factors that allow H. pylori to colonize the human stomach, mechanisms by which H. pylori increases the risk for peptic ulcer disease and non-cardia gastric adenocarcinoma, and potential benefits that H. pylori might confer to humans.

Subfields: Gastroenterology, Surgery

View Paper: https://www.semanticscholar.org/paper/0eb05088d53fa2950c321c4a7e46857c393df75e

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Citations in the corpus

• Epidemiology of Gastric Cancer (2015, background): “pylori is a Gram-negative spiral bacterium with a variety of mechanisms that enable it to colonize the gastric mucosa and evade or modify the host’s immune response [32].”
• The gastric precancerous cascade (2012, background): “pylori are generally absent from areas of complete IM, there are a small percentage of cases with incomplete IM that show adherence of the bacterium to the metaplastic epithelium [72, 73].”