Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

By K. Newton, D. Dugger, Katherine E. Wickliffe, N. Kapoor, M. de Almagro, D. Vučić, L. Komuves, R. Ferrando, D. French, J. Webster and 3 more. Science, 2014

665 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0ea6418bb6b87837af4bfde147345bff6489ad4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Xuejun Jiang

In Immunology

1. Brent R. Stockwell
2. D. Tang
3. R. Kang
4. Guido Kroemer

In Molecular Biology

1. Xuejun Jiang
2. D. Sharma
3. Y. K. Dhuriya

Citations in the corpus

• Necroptosis: a regulated inflammatory mode of cell death (2018, background): “On activation, cIAP1/2 and TRAF2/5 mediate ubiquitination of RIPK1 which resulted in formation of stable complex I and initiate alternative pathway that culminates with cell survival pathway including NF-кB- and MAPK-mediated pathway [28].”
• From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, neutral): “th Ripk3 (survive to adulthood) [119] Ripk3 / (survive to adulthood) [119] Mlkl / (survive to adulthood) [119] Zbp1 / (survive to adulthood) [119] Zbp1Za/Za (survive to adulthood) [37, 259] n yolk Ripk1 (kinase dead RIPK1, survive to birth) [109] Mlkl / Fadd / (survive but develop ALPS) [109] Ripk3 ”
• Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “As mentioned above, RIPK3 operates immediately upstream of MLKL in the signal transduction cascade that precipitates necroptosis (9), in a manner that depends strictly on RIPK3 kinase activity (31).”
• Glutaminolysis and Transferrin Regulate Ferroptosis (2015, background): “However, RIP3 gene deletion did not prevent serum-induced cell death in MEFs, although it completely blocked TNFα-induced necrosis as predicted (Figure 1F, G and Figure S1C).”
• ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways (2016, neutral): “Previous studies identified RIPK3 as a critical regulator determining cell death via necroptotic or apoptotic pathways (24, 25).”