A Pericyte Origin of Spinal Cord Scar Tissue

By C. Göritz, D. O. Dias, N. Tomilin, M. Barbacid, O. Shupliakov, J. Frisén. Science, 2011

826 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/0e856281623d486bd5d95678a6984aba203df59c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. A. Tran
6. J. Silver
7. P. Warren
8. Alexei Verkhratsky

In Developmental Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. J. Silver
6. A. Tran
7. Alexei Verkhratsky
8. J. Burda

In Genetics

1. M. Pekna
2. M. Pekny

Citations in the corpus

• Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition (2011, background): “Pericytes have recently been implicated as the origin of fibroblasts that secrete ECM in the context of renal fibrosis and scar tissue after spinal cord injury (18, 19, 33).”
• Cellular and molecular mechanisms in kidney fibrosis. (2014, neutral): “Therefore, it remains possible that FOXD1lineage cells are hybrid cells regulating both capillary and tubule homeostasis, perhaps bearing similarities to astrocytes in the brain, which are attached to capillaries partially within the CBM, yet have critical connections to neurons (51, 52).”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “It was proposed that these proliferating blood vessel-associated astrocytes regulate migration and proliferation of glial scar forming pericytes (16, 82).”
• Astrocytes: a central element in neurological diseases (2016, background): “Such proliferating blood vessel-associated astrocytes might regulate migration and proliferation of pericytes involved in the glial scar formation [11, 72].”
• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Fibroblasts have also been found in contusive injuries where meninges are intact (268, 270).”
• Reactive gliosis and the multicellular response to CNS damage and disease (2014, neutral): “Fibroblast-related cells, including perivascular fibroblasts, meningeal fibroblasts, and pericytes, contribute to tissue replacement by forming fibrotic scar tissue after severe damage (Göritz et al., 2011; Klapka and Müller, 2006; Logan and Berry, 2002; Soderblom et al., 2013; Winkler et al., 2011)”
• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Pericytes have recently been found to contribute to the fibrotic scar following CNS injury by chronically differentiating into fibroblast-like cells (142, 361).”
• Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “The injury was induced at least 10 days after tamoxifen administration to eliminate any possibil- ity of recombination after injury (Göritz et al., 2011).”
• Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms (2020, background): “The formation of cyst reveals ongoing apoptotic responses while astrocytes undergo necroptosis cell death through TLR4/MyD88 signalling [36].”
• Spinal cord injury: molecular mechanisms and therapeutic interventions (2023, methodology): “By using GlastCreER transgenic mice and a Rosa26-YFP reporter mouse line, a subtype of pericytes named type A pericytes was labeled.(183) Blocking the progeny of type A pericytes results in failure to seal the injured spinal cord.”