Prevalence of impaired glucose tolerance among children and adolescents with marked obesity.

By Ranjana Sinha, G. Fisch, B. Teague, W. Tamborlane, Bruna Banyas, Karin Allen, M. Savoye, Vera Rieger, Sara E. Taksali, Gina Barbetta and 2 more. New England Journal of Medicine, 2002

1,854 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Genetics

View Paper: https://www.semanticscholar.org/paper/0e6b33798ee36c635a2c1e99c405ac1fa5d5233c

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In Endocrinology, Diabetes and Metabolism

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Citations in the corpus

Protein tyrosine phosphatase 1B inhibitors for diabetes (2002, background): “Panel c outlines the mechanism of inhibition of tight-binding inhibitors: competitive (1), non-competitive (2) (when α = 1, (EQN 3; BOX 1)) and”
The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. (2004, background): “The increased prevalence of being overweight in childhood has been paralleled by an increase in the incidence of type 2 diabetes (5) and impaired glucose tolerance (6).”
Overweight and Obesity in Children and Adolescents (2014, background): “Impaired glucose tolerance is a relatively common condition in obese children and adolescents, with a reported prevalence ranging from 15% to greater than 20% (44,45,46).”
Health-enhancing physical activity and sedentary behaviour in children and adolescents (2004, background): “, 2001) and an increased risk of type II diabetes mellitus (Sinha et al., 2002).”
Obesity in children and young people: a crisis in public health. (2004, background): “In a multi-ethnic study of a clinical population of 167 obese children and adolescents in the US, impaired glucose tolerance was present in 25% of younger obese children and 21% of obese adolescents by 2 h tolerance test (127).”
Pathogenesis of Type 2 Diabetes Mellitus (2015, background): “Sinha R, reported 25% of obese children (4 to 10 years of age) and 21%t of obese adolescents (11 to 18 years of age) had IGT and 4% of the obese adolescent has silent T2DM [87].”
The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives (2012, background): “The prevalence of prediabetes is even higher in pediatric populations who have other risk factors, such as obesity, hyperinsulinemia or a family history of diabetes mellitus”
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes (2003, background): “It is of interest that the limited studies currently carried out in these children suggest the co-existence of obesity, insulin resistance and beta-cell dysfunction as occurs in older Type 2 diabetic patients [13].”