Cytokines that promote periodontal tissue destruction.

By D. Graves. The Journal of Periodontology, 2008

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Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis (2010, background): “Periodontitis has similar pathophysiological mechanisms to RA, characterized by the resorption of the supporting bony structure around the teeth and mediated by a variety of pro-inflammatory molecules, including TNF-α, IL-1β, prostaglandin E2 and matrix metalloproteinases (27).”