The PhenX Toolkit: Get the Most From Your Measures

By Carol M. Hamilton, Lisa C. Strader, Joseph Pratt, Deborah R. Maiese, T. Hendershot, R. Kwok, Jane A. Hammond, W. Huggins, Dean Jackman, Huaqin Pan and 14 more. American Journal of Epidemiology, 2011

845 citations recorded by the source corpus.

The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared across multiple studies. To facilitate replication and validation across studies, RTI International (Research Triangle Park, North Carolina) and the National Human Genome Research Institute (Bethesda, Maryland) are collaborating on the consensus measures for Phenotypes and eXposures (PhenX) project. The goal of PhenX is to identify 15 high-priority, well-established, and broadly applicable measures for each of 21 research domains. PhenX measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The selected measures are then made freely available to the scientific community via the PhenX Toolkit. Thus, the PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies. PhenX measures will have the most impact when included at the experimental design stage. The PhenX Toolkit also includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Broad acceptance and use of PhenX measures will promote cross-study comparisons to increase statistical power for identifying and replicating variants associated with complex diseases and with gene-gene and gene-environment interactions.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0e182df4957e1c3cc945c254237e69ccc26e774c

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Citations in the corpus

Psychometric properties of the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PCL-5) in veterans. (2016, neutral): “Consistent with this, the PCL-5 was identified by the PhenX PTSD committee as one of the PTSD instruments that should be used in all standardized assessments (Hamilton et al., 2011).”
Finding Our Way through Phenotypes (2015, methodology): “, PhenX [101]); (ii) an integrative phenotype semantic representation (in Web Ontology Language [OWL] [102]) and its use [103–105] to capture the genetic and environmental context of an observed phenotype [106]; (iii) an ontology of classes defining the anatomical, behavioral, and biological functio”
The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5–21 year olds (2018, neutral): “, 2010), the PhenX toolkit (Hamilton et al., 2011), and the PNC (Satterthwaite et al.”
Demographic, Physical and Mental Health Assessments in the Adolescent Brain and Cognitive Development Study: Rationale and Description (2017, methodology): “ments by the PhenX initiative (Stover et al., 2010; Hamilton et al., 2011; Maiese et al., 2013; McCarty et al., 2014) or other NIH assessment initiatives (Conway et al.”