Macrophages and Metabolism in the Tumor Microenvironment.
By Ilio Vitale, G. Manic, Lisa M. Coussens, Guido Kroemer, L. Galluzzi. Cell Metabolism, 2019
1,518 citations recorded by the source corpus.
Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50% of some solid neoplasms. Most often, TAMs support disease progression and resistance to therapy by providing malignant cells with trophic and nutritional support. However, TAMs can mediate antineoplastic effects, especially in response to pharmacological agents that boost their phagocytic and oxidative functions. Thus, TAMs and their impact on the overall metabolic profile of the TME have a major influence on tumor progression and resistance to therapy, de facto constituting promising targets for the development of novel anticancer agents. Here, we discuss the metabolic circuitries whereby TAMs condition the TME to support tumor growth and how such pathways can be therapeutically targeted.
Subfields: Cancer Research, Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/0e0eb25e641499d28daae9881ef87fd9d53c1633
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In Cancer Research
Citations in the corpus
- Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions (2023, background): “TAMs constitute a plastic and heterogeneous cell population and can account for up to 50% of certain solid tumors.(282) TAMs promote cancer progression by creating an immunosuppressive microenvironment,(283) and enhancing the progression and metastasis of various cancers.”
- Tumor-Associated Macrophages in Tumor Immunity (2020, background): “Such metabolic alterations can also determine the phenotype and function of TAMs in promoting the cancer progression (52).”