Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

By Ulrich M. Zanger, M. Turpeinen, K. Klein, M. Schwab. Analytical and Bioanalytical Chemistry, 2008

614 citations recorded by the source corpus.

Subfields: Biochemistry, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0da90474d4a8b6a7e79e6db3ca5e6e15ced5f251

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Schwab
2. Ulrich M. Zanger

In Oncology

1. M. Schwab
2. Ulrich M. Zanger

In Pharmacology

1. M. Schwab
2. Ulrich M. Zanger

Citations in the corpus

• Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “The cytochromes P450 (CYPs) constitute the major enzyme family capable of catalyzing the oxidative biotransformation of most drugs and other lipophilic xenobiotics and are therefore of particular relevance for clinical pharmacology (Nelson, 2004; Guengerich, 2008; Zanger et al., 2008).”
• Effluent from an NSAID-Manufacturing Plant in Mexico Induces Oxidative Stress on Cyprinus carpio (2013, background): “This may be explained by the fact that in the biotransformation by CYP2C9 of pharmaceuticals evaluated in the present study are formed ROS such as OH. and oxygenated intermediates like the oxy-cytochrome P450 complex [P450 (Fe3+).] as a result of release of the superoxide anion by reaction decouplin”