Overview of cell death signaling pathways
By Zhaoyu Jin, W. El-Deiry. Cancer Biology & Therapy, 2005
1,413 citations recorded by the source corpus.
Apoptosis plays an important role in development and maintenance of tissue homeostasis. Intensive efforts have been made to explore the molecular mechanisms of the apoptotic signaling pathways including the initiation, mediation, execution, and regulation of apoptosis. Caspases are central effectors of apoptosis. Cells undergo apoptosis through two major pathways, namely the extrinsic pathway (death receptor pathway) or the intrinsic pathway (the mitochondrial pathway). Finally, the contents of dead cells are packaged into apoptotic bodies, which are recognized by neighboring cells or macrophages and cleared by phagocytosis. Cellular apoptosis is tightly controlled by complex regulatory networks including balancing pro-survival signals. De-regulation of apoptosis may lead to pathological disorders such as developmental defects, autoimmune diseases, neurodegeneration or cancer. Increasing attention is being focused on alternative signaling pathways leading to cell death including necrosis, autophagy, and mitotic catastrophe. Understanding of cell death signaling pathways is relevant to understanding cancer and to developing more effective therapeutics.
Subfields: Cancer Research, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0da15ea5e1c885dc2548b566381405e45c930bd4
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Citations in the corpus
- Radiation-induced cell death mechanisms (2010, background): “These caspases are crucial for the demolition phase of apoptosis, and their targets include mediators and regulators of apoptosis, structural proteins, cellular DNA repair proteins, and cellcycle-related proteins [ 38 ].”
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis (2010, background): “regulator of this pathway that inhibits caspases and protects mitochondrial integrity (69, 70).”
- Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol (2009, neutral): “In principle, two main pathways can be distinguished, the extrinsic or death receptor pathway and the intrinsic or mitochondrial pathway with the latter being regulated by the Bcl-2 family of proteins [13].”
- Cellular response to hyperosmotic stresses. (2007, background): “There are two basic pathways for apoptosis: an intrinsic (mitochondrial) pathway and an extrinsic (death receptor) pathway (132).”