High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

By C. Linnemann, M. V. Buuren, L. Bies, E. Verdegaal, R. Schotte, J. Calis, Sam Behjati, A. Velds, H. Hilkmann, Dris el Atmioui and 6 more. Nature Medicine, 2014

654 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/0d943c6fed2e4effa6e79db902fc0b87f3ff5a52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Padmanee Sharma
2. P. Greenberg
3. James P. Allison
4. A. Schietinger
5. M. Philip
6. John Sidney
7. Catherine J. Wu
8. Nir Hacohen

In Oncology

1. Padmanee Sharma
2. P. Greenberg
3. James P. Allison
4. Catherine J. Wu
5. A. Schietinger
6. G. Freeman

Citations in the corpus

• Immune Checkpoint Targeting in Cancer Therapy: Towards Combination Strategies with Curative Potential (2015, background): “In contrast, immune checkpoint therapy is inherently multivalent because targeting a single checkpoint can potentially release T cells with specificity for peptides derived from many different antigens present in a tumor, including differentiation, cancer testis, and even neoantigens generated by mu”
• A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction (2020, background): “the final step of experimentally verifying neo-epitopes [13, 14].”